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The major effects of benzodiazepines is to potentiate the effects of the inhibitory neurotransmitter gamma amino butyric acid (GABA). Long term use of benzodiazepines also contributes to increasing oxidative stress (see section?) with the resultant long term effects of lack of energy and premature cell aging.

NAD+ will help to alleviate withdrawal symptoms by reducing neural excitation and also ameliorate the long term physical and emotional effects of these drugs. It is well known that their withdrawal is difficult and may be prolonged, a longer course of therapy may be necessary in comparison to that recommended for alcohol withdrawal.

Practitioners hope to work within National Institute for Health and Care Excellence (NICE) guidelines to withdraw patients from tranquillisers at a pace suited to each individual. They believe tailor-made protocols could help some withdraw in weeks rather than months and years.

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